Therapeutic applications of trans-splicing
نویسندگان
چکیده
منابع مشابه
Self-splicing and trans-splicing ribozymes
The Journal of Clinical Investigation | August 2003 | Volume 112 | Number 3 The splicing activity of Group I and Group II introns can be harnessed as a molecular tool that may potentially revise any gene of interest. Although hurdles remain, progress has been made in the development of these ribozymes for therapeutic application. While gene therapy is showing promise in the treatment of some di...
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About 70% of C. elegans mRNAs are trans-spliced to one of two 22 nucleotide spliced leaders. SL1 is used to trim off the 5' ends of pre-mRNAs and replace them with the SL1 sequence. This processing event is very closely related to cis-splicing, or intron removal. The SL1 sequence is donated by a 100 nt small nuclear ribonucleoprotein particle (snRNP). This snRNP is structurally and functionally...
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A growing body of studies has documented the pathological influence of impaired alternative splicing (AS) events on numerous diseases, including cancer. In addition, the generation of alternatively spliced isoforms is frequently noted to result in drug resistance in many cancer therapies. To gain comprehensive insights into the impacts of AS events on cancer biology and therapeutic developments...
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on the forests, wildlife, and indigenous people of this area, WWF warns. It is not necessary to use this area as there is already a total of 2.3 million hectares of idle or derelict land available for palm oil plantations in Kalimantan, an area greater than the proposed plantation, WWF points out. In addition, oil palm is not recommended for planting in areas more than 200 metres above sea leve...
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To date the Simian Virus 40 (SV40) is the only proven example of a virus that recruits the mechanism of RNA trans-splicing to diversify its sequences and gene products. Thereby, two identical viral transcripts are efficiently joined by homologous trans-splicing triggering the formation of a highly transforming 100 kDa super T antigen. Sequences of other viruses including HIV-1 and the human ade...
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ژورنال
عنوان ژورنال: British Medical Bulletin
سال: 2020
ISSN: 0007-1420,1471-8391
DOI: 10.1093/bmb/ldaa028